Non-atherosclerotic coronary artery disease

Last revised by Rohit Sharma on 15 Jan 2023

Non-atherosclerotic coronary artery disease or non-atherosclerotic coronary artery abnormalities are a heterogeneous group of abnormalities that can cause myocardial ischemia or sudden cardiac death with the exclusion of coronary artery disease 1-3.

Due to the diversity non-atherosclerotic coronary disease is found in all age groups and it is frequently described in younger male individuals and women 1-3.

The non-atherosclerotic coronary disease can be associated with the following 1-5:

The diagnosis of non-atherosclerotic coronary disease can be established on imaging most commonly either cardiac CT or invasive coronary angiography with or without intravascular imaging such as intravascular ultrasound (IVUS) or optical coherence tomography (OCT). Due to the association with sudden cardiac death, the diagnosis is also made on postmortem examinations 1,2.

Causes of nonatherosclerotic coronary artery diseases or abnormalities include the following pathologies 1-9:

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