Citation, DOI, disclosures and article data
Citation:
Feger J, Sharma R, Non-atherosclerotic coronary artery disease. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-160309
Non-atherosclerotic coronary artery disease or non-atherosclerotic coronary artery abnormalities are a heterogeneous group of abnormalities that can cause myocardial ischemia or sudden cardiac death with the exclusion of coronary artery disease 1-3.
Due to the diversity non-atherosclerotic coronary disease is found in all age groups and it is frequently described in younger male individuals and women 1-3.
Associations
The non-atherosclerotic coronary disease can be associated with the following 1-5:
The diagnosis of non-atherosclerotic coronary disease can be established on imaging most commonly either cardiac CT or invasive coronary angiography with or without intravascular imaging such as intravascular ultrasound (IVUS) or optical coherence tomography (OCT). Due to the association with sudden cardiac death, the diagnosis is also made on postmortem examinations 1,2.
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Etiology
Causes of nonatherosclerotic coronary artery diseases or abnormalities include the following pathologies 1-9:
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1. Hill S & Sheppard M. Non-Atherosclerotic Coronary Artery Disease Associated with Sudden Cardiac Death. Heart. 2010;96(14):1119-25. doi:10.1136/hrt.2009.185157 - Pubmed
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2. Corrado D, Thiene G, Cocco P, Frescura C. Non-Atherosclerotic Coronary Artery Disease and Sudden Death in the Young. Br Heart J. 1992;68(6):601-7. doi:10.1136/hrt.68.12.601 - Pubmed
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3. Jinnouchi H, Finn A, Virmani R. Nonatherosclerotic Vascular Disease in Women. Tex Heart Inst J. 2018;45(4):233-5. doi:10.14503/THIJ-18-6675 - Pubmed
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4. Kosmas N, Manolis A, Dagres N, Iliodromitis E. Myocardial Infarction or Acute Coronary Syndrome with Non-Obstructive Coronary Arteries and Sudden Cardiac Death: A Missing Connection. EP Europace. 2020;22(9):1303-10. doi:10.1093/europace/euaa156 - Pubmed
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5. Chandra S, Singh V, Nehra M, Agarwal D, Singh N. ST-Segment Elevation in Non-Atherosclerotic Coronaries: A Brief Overview. Intern Emerg Med. 2011;6(2):129-39. doi:10.1007/s11739-010-0491-5 - Pubmed
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6. Zhou Z, Xu L, Zhang N et al. CT Coronary Angiography Findings in Non-Atherosclerotic Coronary Artery Diseases. Clin Radiol. 2018;73(2):205-13. doi:10.1016/j.crad.2017.07.007 - Pubmed
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7. Cury R, Blankstein R, Leipsic J et al. CAD-RADS™ 2.0 - 2022 Coronary Artery Disease - Reporting and Data System an Expert Consensus Document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Cardiology (ACC), the American College of Radiology (ACR) and the North America Society of Cardiovascular Imaging (NASCI). J Cardiovasc Comput Tomogr. 2022. doi:10.1016/j.jcct.2022.07.002 - Pubmed
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8. Persu A, Dobrowolski P, Gornik H et al. Current Progress in Clinical, Molecular, and Genetic Aspects of Adult Fibromuscular Dysplasia. Cardiovasc Res. 2022;118(1):65-83. doi:10.1093/cvr/cvab086 - Pubmed
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9. Neves D, Bento Â, Fernandes R, Patrício L, Aguiar J. Spontaneous Coronary Artery Dissection: Still a Lot to Learn. Rev Port Cardiol. 2017;36(1):59.e1-5. doi:10.1016/j.repc.2016.06.012 - Pubmed
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