Non-dilated left ventricular cardiomyopathy

Last revised by Henry Knipe on 19 Oct 2023

Non-dilated left ventricular cardiomyopathy (NDLVC) refers to a cardiomyopathy phenotype that affects the left ventricle and is characterized by non-ischemic myocardial scarring or fatty replacement with or without regional or global wall-motion abnormalities, or in the setting of global left ventricular wall-motion abnormalities without the presence of myocardial scarring 1.

This includes cardiomyopathic phenotypes that might have been described as dilated cardiomyopathy without dilated left ventricle, arrhythmogenic left ventricular cardiomyopathy (ALVC), left dominant arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic dilated cardiomyopathy (DCM) 1.

History and etymology

The term non-dilated left ventricular cardiomyopathy has been officially introduced by the European Society of Cardiology (ESC) in their '2023 ESC guidelines for the management of cardiomyopathies' 1. The concept, however, had already been proposed earlier by the ESC working group on myocardial and pericardial diseases under the term hypokinetic non-dilated cardiomyopathy in 2016 2 and publications about non-dilated cardiomyopathy were already made earlier e.g. in 2009 and by the Nigerian physicians Basil N Okeahialam and Felix I Anjorin in 1998 3,4.

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