Non-fibrotic hypersensitivity pneumonitis

Last revised by Liz Silverstone on 17 Sep 2024

Non-fibrotic hypersensitivity pneumonitis is distinguished from fibrotic hypersensitivity pneumonitis by the absence of fibrosis. This classification supersedes the previous division into acute, subacute and chronic.

Radiographic features

CT

Described features include 1:

  • mosaic attenuation pattern: typically three density sign with areas of normal lung interspersed with areas of increased attenuation and multilobar areas of lobular air trapping

  • ill-defined centrilobular or diffuse ground glass opacity which may be upper zone predominant

  • lobular air trapping

Differential diagnosis

Depending on the time course and the amount of exposure to the antigen (e.g., single but massive exposure vs. recurring exposure) the imaging findings may differ and can be quite nonspecific. In general consider differentials for:

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