Non-ketotic hyperglycaemic seizures
Seizures in the context of non-ketotic hyperglycaemia are most frequently reported in middle-age to elderly patients with type 2 diabetes mellitus, with one relatively large study reporting an average age of 61 years without any significant gender predilection 1. It has been reported that up to 25% of patients with non-ketotic hyperglycaemia develop seizures 1. Interestingly, seizures are comparatively very rare in ketotic hyperglycaemia (or diabetic ketoacidosis) 1.
Seizures are seen in early stages of non-ketotic hyperglycaemia, usually days before coma manifests 1-5. Most commonly the seizures are focal motor seizures, with a temporal lobe focus, and are often recurrent (epilepsia partialis continua or partial status epilepticus), however focal seizures with an occipital lobe focus have also been reported 1-5. Symptoms usually resolve upon normalisation of glucose levels 1-5.
The exact underlying pathophysiology of seizures in non-ketotic hyperglycaemia remains unclear 4. Although there are many hypotheses, it is likely that the pathogenesis is multi-factorial, considering 4:
- an acidic pH is required for gamma-aminobutyric acid (GABA) synthesis from glutamic acid, and because ketoacidosis does not occur in non-ketotic hyperglycaemia there theoretically could be a decrease in GABA 4
- patients with type 2 diabetes mellitus, and thus at risk of developing non-ketotic hyperglycaemia, are more likely to have underlying structural and vascular anomalies which may contribute to a higher risk of seizures 4
- patients are often hyponatraemic at presentation which is a known risk factor for developing seizures 4
CT of the brain is often normal throughout the presentation, however regions of decreased density have been reported rarely in the literature 1.
MRI of the brain is the modality of choice for assessing possible non-ketotic hyperglycaemic seizures and demonstrates many features at the epileptogenic focus which would otherwise be atypical and unexpected for a patient with seizures 6-8.
Generally, patients with non-ketotic hyperglycaemic seizures have T2-weighted subcortical regions of hypointensity often with no accompanying anomalies on T1-weighted images or DWI 6-8. Imaging findings gradually resolve after glycaemia correction, however evolution of mild atrophy in the region of the epileptogenic focus has been reported 6. This is in stark contrast to classical expected MR findings of seizures (see status epilepticus), which include regions of T2-weighted hyperintensity and high diffusion signal on DWI, without any significant long-term sequelae 6,9,10.
It is unclear exactly why there is this difference between the imaging features of non-ketotic hyperglycaemic seizures and other seizures, however it has been postulated that perhaps excitotoxic cell damage due to seizure-related excessive synaptic activity in patients with non-ketotic hyperglycaemia may unusually result in the development of excessive free radicals (including iron) which may contribute to cerebral subcortical injury, a process that does not occur without hyperglycaemia 6-8.
Treatment and prognosis
Management is through normalisation of glucose levels 11.
- 1. Singh BM, Strobos RJ. Epilepsia partialis continua associated with nonketotic hyperglycemia: clinical and biochemical profile of 21 patients. Annals of neurology. 8 (2): 155-60. doi:10.1002/ana.410080205 - Pubmed
- 2. Maccario M. Neurological Dysfunction Associated With Nonketotic Hyperglycemia. Archives of Neurology. 19 (5): 525. doi:10.1001/archneur.1968.00480050095009
- 3. Singh BM, Gupta DR, Strobos RJ. Nonketotic hyperglycemia and epilepsia partialis continua. Archives of neurology. 29 (3): 187-90. Pubmed
- 4. James C. Daniels, Sudhansu Chokroverty, Kevin D. Barron. Anacidotic Hyperglycemia and Focal Seizures. Archives of Internal Medicine. 124 (6): 701. doi:10.1001/archinte.1969.00300220053009
- 5. Harden CL, Rosenbaum DH, Daras M. Hyperglycemia presenting with occipital seizures. Epilepsia. 32(2):215-20. doi:10.1111/j.1528-1157.1991.tb05247.x
- 6. Seo DW, Na DG, Na DL, Moon SY, Hong SB. Subcortical hypointensity in partial status epilepticus associated with nonketotic hyperglycemia. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 13 (3): 259-63. Pubmed
- 7. Placidi F, Floris R, Bozzao A, Romigi A, Baviera ME, Tombini M, Izzi F, Sperli F, Marciani MG. Ketotic hyperglycemia and epilepsia partialis continua. Neurology. 57 (3): 534-7. Pubmed
- 8. Raghavendra S, Ashalatha R, Thomas SV, Kesavadas C. Focal neuronal loss, reversible subcortical focal T2 hypointensity in seizures with a nonketotic hyperglycemic hyperosmolar state. Neuroradiology. 49 (4): 299-305. doi:10.1007/s00234-006-0189-6 - Pubmed
- 9. Henry TR, Drury I, Brunberg JA, Pennell PB, McKeever PE, Beydoun A. Focal cerebral magnetic resonance changes associated with partial status epilepticus. Epilepsia. 35 (1): 35-41. Pubmed
- 10. Yaffe K, Ferriero D, Barkovich AJ, Rowley H. Reversible MRI abnormalities following seizures. Neurology. 45 (1): 104-8. Pubmed
- 11. Kumar S. Epilepsia partialis continua stopped by insulin. Journal of the Royal Society of Medicine. 97 (7): 332-3. doi:10.1258/jrsm.97.7.332 - Pubmed