Nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease

Nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease or previously known as Samter syndrome or aspirin or analgesic-induced asthma refers to the constellation of 1-2:

Epidemiology

In adults, prevalence can ranges between 8-20% among those exposed to an oral provocation test (OPT), and around 3-5% among patients who self-report that they have the triad 5.

Treatment and prognosis

Treatment is largely centred around avoiding aspirin, treating underlying asthma and if need be polypectomy (surgical or medical). Unfortunately recurrences are common 2.  

Aspirin desensitization has also been tried with at least some short term improvement 2

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Article information

rID: 6927
System: Head & Neck
Section: Syndromes
Synonyms or Alternate Spellings:
  • Samter syndrome
  • Samter's Syndrome
  • Aspirin induced asthma
  • Analgesic induced asthma
  • Nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease

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