Nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease
Nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease or previously known as Samter syndrome or aspirin or analgesic-induced asthma refers to the constellation of 1-2:
In adults, prevalence can ranges between 8-20% among those exposed to an oral provocation test (OPT), and around 3-5% among patients who self-report that they have the triad 5.
Treatment and prognosis
Treatment is largely centred around avoiding aspirin, treating underlying asthma and if need be polypectomy (surgical or medical). Unfortunately recurrences are common 2.
Aspirin desensitization has also been tried with at least some short term improvement 2.
- 1. Lee KJ. Essential otolaryngology, head & neck surgery. McGraw-Hill Professional. (2003) ISBN:0071373225. Read it at Google Books - Find it at Amazon
- 2. Önerci TM. Nasal Polyposis, Pathogenesis, Medical and Surgical Treatment. Springer Verlag. (2010) ISBN:3642114113. Read it at Google Books - Find it at Amazon
- 3. Tan JHY, Hsu AAL. Nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease phenotype: Topical NSAID and asthma control - A possible oversight link. Respiratory medicine. 118: 1-3. doi:10.1016/j.rmed.2016.07.004 - Pubmed
- 4. Ertoy Karagol HI, Yilmaz O, Topal E, Ceylan A, Bakirtas A. Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease in adolescents. International forum of allergy & rhinology. 5 (5): 392-8. doi:10.1002/alr.21494 - Pubmed
- 5. Sih K, Goldman RD. Nonsteroidal anti-inflammatory drug administration in children with history of wheeze. Canadian family physician Medecin de famille canadien. 62 (8): 633-4. Pubmed