Normal bone marrow signal of the clivus

Bone marrow signal of the clivus changes predictably with age and is well assessed with midline T1 non-fat-saturated, non-contrast images. As is seen in the rest of the body the proportion of yellow (fatty) marrow increases with age. Knowledge of these changes allows diagnosis of the abnormal clivus

Kimura et al1 divided the appearance into three grades, by comparing the clivus to the pons and subcutaneous fat. High signal was similar to subcutaneous fat, whereas low was iso- to slightly hypointense to the pons. It should be pointed out that the figures obtained in the study by Kimura et al, have not been exactly replicated in other studies 2,3, and that the grading proposed is by no means widely used in clinical practice. Nonetheless, it serves as a useful guide when examining MRI of the brain, and relating bone marrow signal to age. 

Classification

  • grade 1: predominantly low signal (>50% of clivus)
  • grade 2: mixed signal (low signal 20-50% of clivus)
  • grade 3: predominantly high signal (>80% of clivus)

The signal will vary according to the age of patients 1

  • patients in their 20's
    • grade 1: 33% of patients
    • grade 2: 33%
    • grade 3: 34%
  • patients in their 50's
    • grade 1: 0%
    • grade 2: 40%
    • grade 3: 60%
  • patients in their 80's
    • grade 1: 0%
    • grade 2: 0%
    • grade 3: 100%

Most importantly, a finding of low signal in elderly patients warrants comment and review of additional imaging and clinical information. 

See also

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