Notch sign (primary CNS lymphoma)

Last revised by Rohit Sharma ◉ on 4 Sep 2022

Citation, DOI, disclosures and article data

Citation:

Sarangi P, Sharma R, Bell D, Notch sign (primary CNS lymphoma). Reference article, Radiopaedia.org (Accessed on 27 Sep 2023) https://doi.org/10.53347/rID-99503

DOI:

https://doi.org/10.53347/rID-99503

Permalink:

https://radiopaedia.org/articles/99503

rID:

99503

Article created:

3 May 2022, Pradosh Kumar Sarangi

Disclosures:

At the time the article was created Pradosh Kumar Sarangi had no recorded disclosures.

View Pradosh Kumar Sarangi's current disclosures

Last revised:

4 Sep 2022, Rohit Sharma ◉

Disclosures:

At the time the article was last revised Rohit Sharma had no financial relationships to ineligible companies to disclose.

View Rohit Sharma's current disclosures

Revisions:

7 times, by 3 contributors - see full revision history and disclosures

Systems:

Central Nervous System, Haematology

Sections:

Signs

Tags:

cases3, refs

The notch sign refers to an abnormally deep depression at the tumor margin in contrast-enhanced MRI in primary CNS lymphoma ¹. It is not an uncommon sign in primary CNS lymphoma and can be seen in both immunocompetent and immunocompromised patients. It suggests an irregular growth pattern as well as pliable and infiltrative properties.

The notch sign is a specific feature for primary CNS lymphoma and can be helpful in differentiating CNS lymphoma in immunocompetent patients from glioblastoma multiforme (GBM) at the time of initial presentation according to one study ².