Nothnagel syndrome is a rare midbrain stroke syndrome that involves the tectum of the midbrain, including the quadrigeminal plate 1-4. Although it can be caused by stroke, especially haemorrhages rather than infarctions, it is more commonly seen due to neoplasm 1-4. Classically, the syndrome involves the oculomotor nerve fascicles and superior cerebellar peduncle, leading to ipsilateral CN III palsy and limb ataxia respectively 1-4.
History and etymology
The syndrome was first described by Hermann Nothnagel (1841-1905), a German-Austrian physician, in 1879 5.
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- 5. Nothnagel H. Corpora quadrigemina. In: Topische Diagnostik der Gehirnkrankheiten. A Hirschwald, 1879:204-220.