Octreotide scintigraphy

Last revised by Yahya Baba on 1 Sep 2023

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Baba Y, Thibodeau R, et al. Octreotide scintigraphy. Reference article, Radiopaedia.org (Accessed on 18 Apr 2024) https://doi.org/10.53347/rID-9705

DOI:

https://doi.org/10.53347/rID-9705

Permalink:

https://radiopaedia.org/articles/9705

rID:

9705

Article created:

13 May 2010, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

1 Sep 2023, Yahya Baba ◉

Disclosures:

At the time the article was last revised Yahya Baba had no financial relationships to ineligible companies to disclose.

View Yahya Baba's current disclosures

Revisions:

21 times, by 12 contributors - see full revision history and disclosures

Systems:

Chest, Gastrointestinal, Paediatrics

Sections:

Imaging Technology

Tags:

radiopharmaceutical

Synonyms:

Octreotide scan
In-111 Octreoscan
Octreoscan

Octreotide scintigraphy uses ¹¹¹In-labelled octreotide, which is a somatostatin analogue; it is also known as Octreoscan, a brand name for ¹¹¹In-labelled pentetreotide. Pentetreotide is a DTPA-conjugated form of octreotide, originally manufactured by Mallinckrodt Nuclear Medicine LLC, which now forms part of Curium.

The radiotracer is characterised by a high affinity of bond with the somatostatin receptor 2 (SST2). It penetrates inside the cell by endocytosis, first held by lysosomes and then transferred to the nucleus ^4,5.

It is particularly useful for the assessment of neuroendocrine tumours, and the Krenning Score is used to grade these, most commonly for peptide receptor radionuclide therapy (PRRT) planning.

Examples include:

Certain non-neuroendocrine tumours can also show uptake in an Octreoscan. Examples include:

Also, certain autoimmune or granulomatous diseases (for example sarcoidosis) may occasionally show octreotide uptake by overexpression of somatostatin receptors^6-8.