Esophageal perforation

Last revised by Dr Yair Glick on 19 Aug 2021

Esophageal perforation is a rare but serious medical emergency with a very high mortality rate, especially if the diagnosis is delayed.

Most patients are in their sixties with a slight male predominance 5

If a perforation is not detected during the procedure or operation, the patient may present with neck, chest or epigastric pain, dysphagia or dyspnea 3,4 although symptoms asides from chest pain (present in 70%) are quite variable 5,6. Subcutaneous emphysema may also be present 4. There is risk of bleeding and infection 1

The lack of a serosal layer may make the esophagus more susceptible to injury than other parts of the gastrointestinal tract 3

  • iatrogenic
  • trauma: both blunt (crush-type injury) and penetrating
    • occurs in <0.1% of blunt chest trauma 2
  • foreign body ingestion
  • corrosive material ingestion
  • esophageal cancer
  • spontaneous rupture post-vomiting (Boerhaave syndrome)

Possible clues on chest radiographs include:

  • most sensitive within the first 24 hours 1
  • patient examined semi-supine (~20 degrees) on the fluoroscopy table
  • a low-osmolar water-soluble agent should be used initially as barium can cause mediastinitis 1
  • esophageal perforation may be represented as mucosal irregularity or extraluminal oral contrast leak
  • some authors suggest the use of small amounts of low or high concentrations of barium if no leak is evident on initial screening with water-soluble contrast 8

The role of CT is usually to look for stigmata of perforation when fluoroscopy is equivocal, and there is persisting suspicion of perforation. These include:

Water-soluble oral contrast can be administered 20 minutes before scanning to demonstrate extraluminal contrast leak. Intravenous contrast is usually administered to delineate the esophageal wall (25-60-second delay) 8.

There is a high mortality rate, estimated between 25 to 50% in some series 1,4, which is significantly increased if the diagnosis is delayed beyond 24 hours 6.

The rarity of this condition means that treatment is not well established and options include surgical or endoscopic management vs. medical management 5,6

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Cases and figures

  • Case 1: post instrumentation
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  • Case 2: spontaneous
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  • Case 3
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  • Case 4: with penetrating trauma
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  • Case 5: Boerhaave syndrome
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  • Case 6: from swallowed foreign body
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  • Case 7: post gastroscopy
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  • Case 8
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  • Case 9
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  • Case 10: esophageal rupture (gross pathology)
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  • Case 11: iatrogenic esophageal perforation
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  • Case 12: complicated by oesophagopulmonary fistula and lung abscess
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  • Case 13: leak into pleural space
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  • Case 14
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  • Case 15: with esophageal-pleural fistula
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  • Case 16: from chicken bone
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