Opticospinal multiple sclerosis
Opticospinal multiple sclerosis (OSMS) is a demyelinating disease and has been considered a variant of multiple sclerosis (MS) encountered in Asian populations, who are generally rarely affected by normal multiple sclerosis. It has similar clinical and imaging features to neuromyelitis optica (NMO) and may in fact represent the same disease, in a different population 1-2.
The identification of anti-aquaporin 4 IgG antibodies in NMO has naturally lead to them being sought in patients with OSMS, with varying results, ranging form 35-90% 1. Although this higher than positive rates in patients with conventional MS, whether or not NMO and OSMS are the same disease remains to be fully elucidated.
As the imaging appearances are similar/identical, please refer to the article on neuromyelitis optica (NMO) for further details.
- 1. Jun-ichi Kira, Takuya Matsushita, Noriko Isobe, Takaaki Ishizu. Opticospinal multiple sclerosis in Japanese. Neurology Asia 2008; 13 : 167 – 173 Full Text PDF
- 2. Kira J. Neuromyelitis optica and opticospinal multiple sclerosis: Mechanisms and pathogenesis. Pathophysiology. 2011;18 (1): 69-79. doi:10.1016/j.pathophys.2010.04.008 - Pubmed citation
Related Radiopaedia articles
White matter disorders
- white matter
- normal myelination
white matter disorders
- anti-MOG associated encephalomyelitis
- Guillain-Barre Syndrome (GBS)
- chronic inflammatory demyelinating polyneuropathy (CIDP)
- transverse myelitis
- tumefactive demyelinating lesions
- acute disseminated encephalomyelitis (ADEM) and acute hemorrhagic encephalomyelitis (AHEM)
- neuromyelitis optica (NMO) (Devic disease)
multiple sclerosis (MS)
- McDonald diagnostic criteria for MS (current 2017 revision)
- radiologically isolated syndrome (RIS)
- clinically isolated syndrome (CIS)
- dysmyelinating disorders
- hypomyelinating disorders