Oral cholecystography was a procedure used to image the gallbladder, now largely superseded by ultrasound and MRCP. It was first described by Graham et. al in 1925, using sodium tetraiodophenolphthalein.
Although rarely performed now, more modern techniques used other cholegraphic agents such as iopanoic acid and ipodate. Following oral administration, the contrast agent gets absorbed by the bowel and concentrated in the gallbladder. Radiolucent gallstones may then be outlined as filling defects on fluoroscopic imaging.
- 1. Cholecystography: the use of sodium tetraiodophenolphthalein, Evarts A. Graham, M.D.; Warren H. Cole, M.D.; Glover H. Copher, M.D.
- 2. Side Effects of Radiographic Contrast Media: Pathogenesis, Risk Factors, and Prevention, Michele Andreucci, Richard Solomon and Adis Tasanarong