Organ of Zuckerkandl
Citation, DOI, disclosures and article data
At the time the article was created Bruno Di Muzio had no recorded disclosures.View Bruno Di Muzio's current disclosures
At the time the article was last revised Michael P Hartung had the following disclosures:
- Otsuka Pharmaceutical, Consultant (past)
- Innovenn, Inc, Consultant (past)
These were assessed during peer review and were determined to not be relevant to the changes that were made.View Michael P Hartung's current disclosures
The organ of Zuckerkandl comprises of a small mass of chromaffin cells derived from neural crest located along the aorta, beginning cranial to the superior mesenteric artery or renal arteries and extending to the level of the aortic bifurcation or just beyond. The highest concentration is typically seen at the origin of the inferior mesenteric artery.
Its physiological role is thought to be of greatest importance during the early gestational period as a homeostatic regulator of blood pressure, secreting catecholamines into the fetal circulation. The organ regresses at the end of gestation and following birth to form the aorticosympathetic group of the adult paraganglia.
The organs of Zuckerkandl are not often visualized radiologically unless they are involved in a pathologic process, including:
History and etymology
It was first described in 1901 by Emil Zuckerkandl (1849-1910) 4, a professor of anatomy at the University of Vienna.
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- 2. Dluhy RG. Pheochromocytoma--death of an axiom. N. Engl. J. Med. 2002;346 (19): 1486-8. doi:10.1056/NEJM200205093461911 - Pubmed citation
- 3. Berdon WE, Stylianos S, Ruzal-shapiro C et-al. Neuroblastoma arising from the organ of Zuckerkandl: an unusual site with a favorable biologic outcome. Pediatr Radiol. 1999;29 (7): 497-502. - Pubmed citation
- 4. Winer L, Jha P, Cowan SW et-al. Emil Zuckerkandl, M.D. (1849-1910): Bridging Anatomic Study and the Operating Room Table. (2016) The American surgeon. 82 (3): 189-91. Pubmed