Osteoblastomas are rare bone-forming tumors that may be locally aggressive. They are larger (>1.5-2 cm) and tend to affect the axial skeleton more often than their histologic relative, osteoid osteoma.
They account for 1-3% of all primary bone tumors 2,3. Patients typically present around the second to third decades of life. There is a recognized male predilection with a male to female ratio of approximately 2.5:1.
With spinal lesions, painful scoliosis is a common presenting symptom. Otherwise, it presents with an insidious onset of dull pain, worse at night, with minimal response to salicylates (only 7% of patients respond, unlike osteoid osteoma). The area will characteristically be swollen and tender with a decreased range of motion.
Osteoblastoma is histologically similar to an osteoid osteoma but they are larger. They are bone- and osteoid-forming and is comprised of osteoblasts. There is high associated vascularity.
- spinal column: ~40% (range 32-46% 2); often involves the posterior column
- cervical spine: 9-39% of all spinal lesions 2
- sacrum: 17% of all spinal lesions 3
- usually located in the metaphysis and distal diaphysis of the long bones
- aggressive (malignant) osteoblastoma: has a high of number epithelioid osteoblasts with nuclear atypia
Osteoblastomas can have a wide range of radiographic patterns. Lesions are typically larger than 1.5-2 cm in size although smaller lesions may occur 4,5.
- lesions are predominantly lytic, with a rim of reactive sclerosis
- tend to be expansive
- internal calcification may sometimes be present
- an associated soft tissue mass may also be present
- demonstrate a rapid increase in size with associated cortical expansion in the vast majority of patients, sometimes with cortical destruction
- there may be surrounding sclerosis or periostitis in up to 50%
- there may be a secondary aneurysmal bone cyst in 20%
- similar to the radiograph, lesions are often demonstrated as predominantly lytic
- internal matrix mineralization is better appreciated on CT
MRI features tend to be non-specific and often overestimate the lesion 9:
- T1: typically hypo to isointense on T1 with areas of decreased intensity that correspond to foci of calcification
T2: typically isointense to hypointense on T2 with foci of decreased intensity corresponding to the foci of calcification
- a high signal may be seen in surrounding bone marrow and soft tissues due to edema "flare phenomenon" 11
- C+ (Gd): this is a highly vascular tumor and therefore typically avidly enhances, with associated enhancement of the surrounding soft tissues 9
- Tc-99m MDP or HMDL: often shows intense uptake although this is non-specific and is typical in all lesions exhibiting increased bone turnover
Treatment and prognosis
Radical surgical excision is often the treatment of choice. Pre-operative embolization is commonly carried out to reduce bleeding risk although surgery needs to be performed at a very short time interval in order to avoid reconstitution of collateral blood supply. Percutaneous ablation is an emerging modality for treatment of these lesions (as well as osteoid osteoma) 10.
Lesions are prone to extensive intraoperative bleeding due to intrinsic vascularity.
- osteoid osteoma: <1.5-2 cm
- 1. Mcleod RA, Dahlin DC, Beabout JW. The spectrum of osteoblastoma. AJR Am J Roentgenol. 1976;126 (2): 321-5. AJR Am J Roentgenol (abstract) - Pubmed citation
- 2. Trübenbach J, Nägele T, Bauer T et-al. Preoperative embolization of cervical spine osteoblastomas: report of three cases. AJNR Am J Neuroradiol. 2006;27 (9): 1910-2. AJNR Am J Neuroradiol (full text) - Pubmed citation
- 3. Llauger J, Palmer J, Amores S et-al. Primary tumors of the sacrum: diagnostic imaging. AJR Am J Roentgenol. 2000;174 (2): 417-24. AJR Am J Roentgenol (full text) - Pubmed citation
- 4. Eisenberg RL. Bubbly lesions of bone. AJR Am J Roentgenol. 2009;193 (2): W79-94. doi:10.2214/AJR.09.2964 - Pubmed citation
- 5. Rodriguez DP, Poussaint TY. Imaging of back pain in children. AJNR Am J Neuroradiol. 2010;31 (5): 787-802. doi:10.3174/ajnr.A1832 - Pubmed citation
- 6. Kroon HM, Schurmans J. Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology. 1990;175 (3): 783-90. Radiology (abstract) - Pubmed citation
- 7. Cerase A, Priolo F. Skeletal benign bone-forming lesions. Eur J Radiol. 1998;27 Suppl 1 : S91-7. - Pubmed citation
- 8. Youssef BA, Haddad MC, Zahrani A et-al. Osteoid osteoma and osteoblastoma: MRI appearances and the significance of ring enhancement. Eur Radiol. 1996;6 (3): 291-6. - Pubmed citation
- 9. Shaikh MI, Saifuddin A, Pringle J et-al. Spinal osteoblastoma: CT and MR imaging with pathological correlation. Skeletal Radiol. 1999;28 (1): 33-40. Skeletal Radiol. (link) - Pubmed citation
- 10. Atesok KI, Alman BA, Schemitsch EH et-al. Osteoid osteoma and osteoblastoma. J Am Acad Orthop Surg. 2012;19 (11): 678-89. Pubmed citation
- 11. Crim JR, Mirra JM, Eckardt JJ et-al. Widespread inflammatory response to osteoblastoma: the flare phenomenon. Radiology. 1990;177 (3): 835-6. doi:10.1148/radiology.177.3.2243998 - Pubmed citation
Related Radiopaedia articles
The differential diagnosis for bone tumors is dependent on the age of the patient, with a very different set of differentials for the pediatric patient.
- bone-forming tumors
- cartilage-forming tumors
- chondromyxoid fibroma
- juxtacortical chondroma
- fibrous bone lesions
- bone marrow tumors
- other bone tumors or tumor-like lesions
- aneurysmal bone cyst
- benign fibrous histiocytoma
- giant cell tumor of bone
- Gorham massive osteolysis
- haemophilic pseudotumor
- intradiploic epidermoid cyst
- intraosseous lipoma
- musculoskeletal angiosarcoma
- musculoskeletal hemangiopericytoma
- primary intraosseous hemangioma
- post-traumatic cystic bone lesion
- simple bone cyst
- impending fracture risk