Osteomesopyknosis is a genetic disorder transmitted as an autosomal dominant trait, and is characterised by osteosclerosis of the axial spine, pelvis and proximal areas of the long bones. Its importance is due to recognizing this as a benign entity and not requiring more radiological work up.
Osteomesopyknosis presents with chronic, low-grade back pain in the thoracic and lumbar regions. Life expectancy is normal. Height and intellect are not affected.
Dense diffuse osteosclerosis of axial spine, pelvis and proximal long bones.
The radiographic appearance may be confused with:
- diffuse sclerotic metastases
- renal osteodystrophy
- other diffuse osteosclerotic disorders, e.g. osteopetrosis, pyknodysostosis
History and etymology
The term osteomesopyknosis was coined by Maroteaux in 1980 after being described by Simon et al. in 1979.
- 1. Maroteaux P. Osteomesopycnosis. A new autosomal dominant osteosclerosing bone disease (author's transl). Arch. Fr. Pediatr. 1981;37 (3): 153-7. Pubmed citation
- 2. Nakamura M, Masumi S, Nakamura M. Osteomesopycnosis: the first report from Japan. J Bone Joint Surg Br. 1996;78 (1): 145-7. Pubmed citation