Last revised by Daniel J Bell on 13 Oct 2020

Osteomesopyknosis is a genetic disorder transmitted as an autosomal dominant trait and is characterized by osteosclerosis of the axial spine, pelvis and proximal areas of the long bones. Its importance is due to recognizing this as a benign entity and not requiring more radiological work up.

Osteomesopyknosis presents with chronic, low-grade back pain in the thoracic and lumbar regions. Life expectancy is normal. Height and intellect are not affected.

Dense diffuse osteosclerosis of axial spine, pelvis and proximal long bones.

The term osteomesopyknosis was coined by Maroteaux in 1980 after being described by Simon et al. in 1979 1

The radiographic appearance may be confused with:

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