Citation, DOI and article data
Ovarian cystadenofibromas are a relatively uncommon benign epithelial ovarian tumor where the fibrous stroma remains a dominant component of the neoplasm. As a group, they are thought to represent ~1.7 % of all benign ovarian tumors 3.
Lesions can be bilateral in ~15% of cases. Although generally classified as an epithelial tumor, a cystadenofibroma contains both epithelial and stromal components.
Recognized histological subtypes include 3,5:
- serous cystadenofibroma of the ovary
- mucinous cystadenofibroma of the ovary
- endometrioid cystadenofibroma of the ovary
- clear cell cystadenofibroma of the ovary
- mixed cystadenofibroma of the ovary
Almost all cystadenofibromas are predominantly cystic on ultrasound with septations seen in ~30% of cases. Papillary projections or solid nodules have been sonographically seen in just over 50% of cases. Vascularization can be present in just under 50% of cases with a typical pattern of peripheral vascularization with scattered vessels of high blood flow impedance 9.
They can have either a pure cystic or complex cystic pattern with the solid components having a nodular or trabecular pattern 3.
- T2: due to the stromal components the fibrous septa often have low signal while the cystic components can have high signal; this may give a "black sponge" like appearance 7
- T1 C+ (Gd): septated component may show moderate enhancement 8
Treatment and prognosis
They generally tend to be benign tumors although the degree of epithelial proliferation and its relation to the stromal component of the tumor can be used for their classification as benign, borderline or malignant 5.
- 1. Jung SE, Lee JM, Rha SE et-al. CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22 (6): 1305-25. doi:10.1148/rg.226025033 - Pubmed citation
- 2. Wasnik A, Elsayes K. Ovarian cystadenofibroma: A masquerader of malignancy. Indian J Radiol Imaging. 2010;20 (4): 297-9. doi:10.4103/0971-3026.73538 - Free text at pubmed - Pubmed citation
- 3. Cho SM, Byun JY, Rha SE et-al. CT and MRI findings of cystadenofibromas of the ovary. Eur Radiol. 2004;14 (5): 798-804. doi:10.1007/s00330-003-2060-z - Pubmed citation
- 4. Jung DC, Kim SH, Kim SH. MR imaging findings of ovarian cystadenofibroma and cystadenocarcinofibroma: clues for the differential diagnosis. Korean J Radiol. 7 (3): 199-204. Korean J Radiol (link) - Free text at pubmed - Pubmed citation
- 5. Byun JY. MR imaging findings of ovarian cystadenofibroma: clues for making the differential diagnosis from ovarian malignancy. Korean J Radiol. 7 (3): 153-5. Korean J Radiol (link) - Free text at pubmed - Pubmed citation
- 6. Outwater EK, Siegelman ES, Talerman A et-al. Ovarian fibromas and cystadenofibromas: MRI features of the fibrous component. J Magn Reson Imaging. 7 (3): 465-71. - Pubmed citation
- 7. Korbin CD, Brown DL, Welch WR. Paraovarian cystadenomas and cystadenofibromas: sonographic characteristics in 14 cases. Radiology. 1998;208 (2): 459-62. Radiology (abstract) - Pubmed citation
- 7. Takeuchi M, Matsuzaki K, Kusaka M et-al. Ovarian cystadenofibromas: characteristic magnetic resonance findings with pathologic correlation. J Comput Assist Tomogr. 27 (6): 871-3. J Comput Assist Tomogr (link) - Pubmed citation
- 8. Kim KA, Park CM, Lee JH et-al. Benign ovarian tumors with solid and cystic components that mimic malignancy. AJR Am J Roentgenol. 2004;182 (5): 1259-65. AJR Am J Roentgenol (full text) - Pubmed citation
- 9. Alcázar JL, Errasti T, Mínguez JA et-al. Sonographic features of ovarian cystadenofibromas: spectrum of findings. J Ultrasound Med. 2001;20 (8): 915-9. J Ultrasound Med (abstract) - Pubmed citation
- 10. Eurorad teaching files : Case 9059