Ovarian fibrosarcoma

Last revised by Dr Joachim Feger on 24 Nov 2020

Ovarian fibrosarcoma is a malignant mesenchymal fibroblastic tumor of the ovary that has multiple mitotic figures which is the most important factor in histopathological diagnosis (4 or more mitotic figure per 10 high power fields). 

Ovarian fibrosarcoma is a very rare malignant ovarian tumors, usually seen in peri- or post-menopausal women. 

Ovarian fibrosarcoma is a unique fibrous tumor with high mitotic figures arises from the ovary. It can be de novo or arise from an ovarian fibroma as malignant transformation.

A large unilateral ovarian heterogeneous solid mass frequently has areas of hemorrhage and or cystic degeneration. It may extend beyond boundaries of the ovary.

Ovarian fibrosarcoma has a poor prognosis and treatment consists of complete surgical resection followed by chemotherapy.

Poor prognostic factors are a very high mitotic figure, necrosis and less collagen.

Consider other unilateral ovarian tumors.

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