Citation, DOI & article data
Ovarian fibrosarcoma is a malignant mesenchymal fibroblastic tumor of the ovary that has multiple mitotic figures which is the most important factor in histopathological diagnosis (4 or more mitotic figure per 10 high power fields).
Ovarian fibrosarcoma is a very rare malignant ovarian tumors, usually seen in peri- or post-menopausal women.
Ovarian fibrosarcoma is a unique fibrous tumor with high mitotic figures arises from the ovary. It can be de novo or arise from an ovarian fibroma as malignant transformation.
A large unilateral ovarian heterogeneous solid mass frequently has areas of hemorrhage and or cystic degeneration. It may extend beyond boundaries of the ovary.
Treatment and prognosis
Ovarian fibrosarcoma has a poor prognosis and treatment consists of complete surgical resection followed by chemotherapy.
Poor prognostic factors are a very high mitotic figure, necrosis and less collagen.
Consider other unilateral ovarian tumors.
- 1. Ray S, Biswas BK, Mukhopadhyay S. Giant primary ovarian fibrosarcoma: Case report and review of pitfalls. J Cytol. 2012;29 (4): 255-7. doi:10.4103/0970-9371.103946 - Free text at pubmed - Pubmed citation
- 2. Kaku S, Takeshima N, Akiyama F et-al. A unique fibrous tumor of the ovary: fibrosarcoma or mitotically active cellular fibroma?. Anticancer Res. 2008;27 (6C): 4365-9. Anticancer Res. (full text) - Pubmed citation