Ovarian fibrosarcoma

Last revised by Mohammad Taghi Niknejad on 1 Nov 2022

Ovarian fibrosarcoma is a malignant mesenchymal fibroblastic tumour of the ovary that has multiple mitotic figures which is the most important factor in histopathological diagnosis (4 or more mitotic figure per 10 high power fields). 

Ovarian fibrosarcoma is a very rare malignant ovarian tumours, usually seen in peri- or post-menopausal women. 

Ovarian fibrosarcoma is a unique fibrous tumour with high mitotic figures arises from the ovary. It can be de novo or arise from an ovarian fibroma as malignant transformation.

A large unilateral ovarian heterogeneous solid mass frequently has areas of haemorrhage and or cystic degeneration. It may extend beyond boundaries of the ovary.

Ovarian fibrosarcoma has a poor prognosis and treatment consists of complete surgical resection followed by chemotherapy.

Poor prognostic factors are a very high mitotic figure, necrosis and less collagen.

Consider other unilateral ovarian tumours.

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