P16 is a widely used immunohistochemical marker. It can be expressed in other neoplasms and in several normal human tissues. It can play an important role in gynaecological malignancy and is a surrogate marker for HSILs (high-grade squamous intraepithelial lesions). It has also been employed to facilitate accurate diagnosis of HPV-related cervical dysplasia (especially CIN2 and CIN3).

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Article information

rID: 54445
Section: Pathology
Synonyms or Alternate Spellings:
  • P16 immunohistochemistry

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