Paclitaxel lung toxicity

Last revised by Dr Rohit Sharma on 12 Jul 2021

Paclitaxel lung toxicity is a form of drug induced lung disease that can precipitate following the use of paclitaxel which is a chemotherapeutic agent commonly used in the treatment of breast, ovarian, and non-small cell lung cancers.

Two forms have been described:

  • hypersensitivity reactions 1
    • thought to occur in around 3-30% of treated patients
    • most frequently manifest as dyspnea, bronchospasm, urticaria, hypotension, and erythematous rashes
  • acute bilateral pneumonitis 2
    • thought to occur in less than 1% of patients receiving 3-hour infusions of paclitaxel

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.