Pancoast syndrome

Pancoast syndrome (historically known as Ciuffini-Pancoast-Tobías syndrome, Hare syndrome or variation thereof) results from involvement of the brachial plexus and sympathetic chain by a Pancoast tumor or, less commonly, from other tumors - or even non-malignant disease - involving the lung apex.

Clinical presentation

The syndrome consists of:

  1. shoulder pain
  2. C8-T2 radicular pain
  3. Horner syndrome

The classical syndrome is uncommon, with Horner syndrome present in only 25%.

History and etymology

Pancoast syndrome as a result of apical lung tumors was described in a number of publications (by Hare in 1838, Ciuffini in 1911 and Tobias in 1932) before Pancoast reported it using the term 'superior pulmonary sulcus tumor' 2-4

  • Edward Selleck Hare (1812-1838), British physician
  • Publio Ciuffini (18??-19??), Italian physician
    • Ciuffini, is mentioned in non-referenced sources 2, an original reference remains elusive
  • Henry Khunrath Pancoast (1875-1939), American radiologist, Philadelphia
  • Jose W Tobias, Argentine physician, Buenos Aires 4
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Article information

rID: 1828
Section: Syndromes
Synonyms or Alternate Spellings:
  • Ciuffini Pancoast Tobías syndrome
  • Ciuffini-Tobías syndrome
  • Ciuffini-Pancoast syndrome
  • Ciuffini-Pancoast-Tobías syndrome
  • Hare syndrome
  • Pancoast-Tobías syndrome
  • Tobías syndrome

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