Pancreatic intraepithelial neoplasia

Last revised by Dr Jeremy Jones on 20 Sep 2021

Pancreatic intraepithelial neoplasia (PanIN) is a precursor lesion to pancreatic ductal adenocarcinoma, but the frequency at which this transition occurs is unknown. 

Increasing incidence with age 1. Risk factors:

Mostly flat lesions (occasionally papillary), consisting of varying degrees of epithelial atypia and dysplasia. They are histologically classified as low-grade or high-grade.

More commonly located in the pancreatic head 1

Most are <5 mm, although they may be in the 5-10 mm range.

May produce unifocal or multifocal lobulocentric pancreatic atrophy but a preoperative diagnosis of PanIN is extremely difficult as it is a microscopic lesion 2,4

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