Pancreatic intraepithelial neoplasia
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Pancreatic intraepithelial neoplasia (PanIN) is a precursor lesion to pancreatic ductal adenocarcinoma, but the frequency at which this transition occurs is unknown.
Increasing incidence with age 1. Risk factors:
- pancreatic lipomatosis 3
Mostly flat lesions (occasionally papillary), consisting of varying degrees of epithelial atypia and dysplasia. They are histologically classified as low-grade or high-grade.
More commonly located in the pancreatic head 1.
Most are <5 mm, although they may be in the 5-10 mm range.
May produce unifocal or multifocal lobulocentric pancreatic atrophy but a preoperative diagnosis of PanIN is extremely difficult as it is a microscopic lesion 2,4.
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