Pancreatic mesenchymal neoplasms

Last revised by Dr Jeremy Jones on 20 Sep 2021

Pancreatic mesenchymal neoplasms (or pancreatic nonepithelial neoplasms) are a group of rare pancreatic neoplasms that arise from the structural elements of the pancreas (nerves, fat, lymph), rather than from the exocrine or endocrine cells of the pancreas. Neoplasms from exocrine and endocrine cells result in more familiar pancreatic neoplasms such as pancreatic ductal adenocarcinoma, IPMN, and pancreatic endocrine tumors (formerly termed "islet cell tumors").

Pancreatic mesenchymal neoplasms are rare and represent at most 1-2% of pancreatic neoplasms 2.

Pancreatic nonepithelial tumors can be broadly divided into those that are benign and those that are malignant.

A disparate group of tumors, they have many different imaging appearances, based on their underlying histology. As a group, these neoplasms tend to better-marginated than the more infiltrative pancreatic ductal adenocarcinoma 1.

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