Last revised by Marcos Gil Alberto da Veiga on 12 Jan 2020

Pandystrophies are neurological diseases that demonstrate both white and grey-matter involvement, as opposed to leukodystrophies (dominated by white matter involvement) or poliodystrophies (dominated by grey matter involvement).

Most metabolic diseases with central nervous system involvement fall into this category, as exclusively white or gray matter involvement is quite uncommon.

For example, archetypal leukodystrophies such as Canavan disease or Krabbe disease, present pallido-thalamic and putaminal lesions, respectively.

In fact, a grey matter neuroimaging abnormality can be caused by myelin breakdown, and a white matter neuroimaging abnormality can be a reflexion of secondary neuronal degeneration. 

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