Citation, DOI, disclosures and article data
At the time the article was created Azza Elgendy had no recorded disclosures.View Azza Elgendy's current disclosures
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The Papez circuit involves different structures of the brain including 2:
- hippocampus and adjacent cortex (entorhinal cortex)
- mammillary bodies
- anterior nucleus of the thalamus
Information from cortical association areas passes to the hippocampus via the cingulate gyrus, cingulum and parahippocampal gyrus. After information processing in the hippocampus, signals are transferred to the hypothalamus (mammillary body) via the fornix. Completion of the circuit and feedback to the cortex is accomplished through mammillothalamic fibers, relaying information from the hypothalamus to the anterior nucleus of the thalamus. The anterior nucleus of the thalamus projects fibers to the cingulate gyrus, cingulum and parahippocampal gyrus back to the hippocampus.
In a more succinct format 2:
Hippocampus → fornix → mammillary body → mammillothalamic fibers→ thalamus (anterior nucleus) → cingulum→ entorhinal cortex → hippocampal formation.
MRI and DTI (diffusion tensor imaging)
The pathway described above can be imaged using MRI and diffusion tensor imaging (DTI) in particular.
History and etymology
In 1930, James Papez suggested that the cognitive activity in the cortex affects the expression of emotions through connections to the hypothalamus and hippocampus. In Papez’s proposal, the hypothalamus regulates the autonomic nervous system activity during the expressions of emotions. Subsequently Paul MacLean modified Papez’s proposal to include the basal forebrain, amygdala and prefrontal cortex, and named it the limbic system. Recent studies show that Papez circuit has a more significant role in memory functions than in emotions 1,2.
- 1. Burt AM. Textbook of neuroanatomy. Saunders. ISBN:0721621996. Read it at Google Books - Find it at Amazon
- 2. Shah A, Jhawar SS, Goel A. Analysis of the anatomy of the Papez circuit and adjoining limbic system by fiber dissection techniques. J Clin Neurosci. 2012;19 (2): 289-98. doi:10.1016/j.jocn.2011.04.039 - Pubmed citation
- 3.Vertes R, Albo Z, Viana Di Prisco G. Neuroscience. 2001;104 (3): . doi:10.1016/S0306-4522(01)00131-2