Papillary cystadenomas of the epididymis are the second most common benign tumours of the epididymis after adenomatoid tumours. They are more common in young men. Approximately 30% of the patients have von Hippel Lindau disease and approximately 10% to 40% of patients with von Hippel-Lindau disease have papillary cystadenoma.
Papillary cystadenomas are usually asymptomatic.
Lesions are usually arising from the head of the epididymis and can present as a cystic lesion with a thick wall and several peripheral solid nodules with increased vascularity, partially or completely cystic or solid lesion and measuring up to 3 cm in diameter.