Papillary predominant adenocarcinoma of lung
Papillary predominant adenocarcinoma of lung is a subtype of adenocarcinoma of the lung.
It may account for 7-12% of all lung adenocarcinomas. There may be predilection in female non smokers 1.
It this form papillary structures replace the underlying alveolar architecture. True papillary adenocarcinoma is usually diagnosed when the pathological features constitute >75% of the tumour on histopathology.
Variable appearances have been described randing from a solitary pulmonary nodule, as a mass containing internal bubble lucencies with surrounding ground-glass opacity and satellite micronodules or as a triangular mass with satellite micronodules 2.
Treatment and prognosis
The presence of micropapillary component in papillary carcinoma has been associated with early lymph node metastasis, intrapulmonary metastasis and a significantly lower 5-year survival rate 1.
- 1. Karmakar S, Nath A, Neyaz Z, Agarwal V, Ahsan S. Primary papillary adenocarcinoma of the lung: Report of two cases. Lung India : official organ of Indian Chest Society. 34 (3): 299-302. doi:10.4103/lungindia.lungindia_467_15 - Pubmed
- 2. Hwang JH, Lee KS, Han J, Kim TS, Lee JY, Kim J. Papillary adenocarcinoma of the lung: radiologic and pathologic findings. Journal of computer assisted tomography. 23 (1): 114-7. Pubmed
- 3. Silver SA, Askin FB. True papillary carcinoma of the lung: a distinct clinicopathologic entity. The American journal of surgical pathology. 21 (1): 43-51. Pubmed
- 4. Jian Z, Tomizawa Y, Yanagitani N, Iijima H, Sano T, Nakajima T. Papillary adenocarcinoma of the lung is a more advanced adenocarcinoma than bronchioloalveolar carcinoma that is composed of two distinct histological subtypes. Pathology international. 55 (10): 619-25. doi:10.1111/j.1440-1827.2005.01879.x - Pubmed