Papillary predominant adenocarcinoma of the lung
Papillary predominant adenocarcinoma of the lung is a subtype of adenocarcinoma of the lung.
It may account for 7-12% of all lung adenocarcinomas. There may be predilection in female non-smokers 1.
It this form papillary structures replace the underlying alveolar architecture. True papillary adenocarcinoma is usually diagnosed when the pathological features constitute >75% of the tumour on histopathology.
Variable appearances have been described ranging from a solitary pulmonary nodule, as a mass containing internal bubble lucencies with surrounding ground-glass opacity and satellite micronodules or as a triangular mass with satellite micronodules 2.
Treatment and prognosis
The presence of a micropapillary component in papillary carcinoma has been associated with early lymph node metastasis, intrapulmonary metastasis and a significantly lower 5-year survival rate 1.
- 1. Karmakar S, Nath A, Neyaz Z, Agarwal V, Ahsan S. Primary papillary adenocarcinoma of the lung: Report of two cases. Lung India : official organ of Indian Chest Society. 34 (3): 299-302. doi:10.4103/lungindia.lungindia_467_15 - Pubmed
- 2. Hwang JH, Lee KS, Han J, Kim TS, Lee JY, Kim J. Papillary adenocarcinoma of the lung: radiologic and pathologic findings. Journal of computer assisted tomography. 23 (1): 114-7. Pubmed
- 3. Silver SA, Askin FB. True papillary carcinoma of the lung: a distinct clinicopathologic entity. The American journal of surgical pathology. 21 (1): 43-51. Pubmed
- 4. Jian Z, Tomizawa Y, Yanagitani N, Iijima H, Sano T, Nakajima T. Papillary adenocarcinoma of the lung is a more advanced adenocarcinoma than bronchioloalveolar carcinoma that is composed of two distinct histological subtypes. Pathology international. 55 (10): 619-25. doi:10.1111/j.1440-1827.2005.01879.x - Pubmed
lung cancer: an overview
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