Papillary serous carcinoma of the endometrium

Papillary serous carcinoma (PSC) of the endometrium is an uncommon histological subtype of endometrial cancer. It is considered type II endometrial adenocarcinoma and has a clinically aggressive form with early extension of the tumour via Fallopian tubes into the peritoneum and peritoneal seeding which accounts for its poorer prognosis compared to the other adenocarcinomas of the uterus. This is thought to closely resemble ovarian papillary serous carcinoma 1. This subtype only comprises 5-10% of endometrial carcinomas 2

Pathology

Like is ovarian counterpart it is characterised by papillary projections and frequently contains psammoma bodies (may be found in ~1/3 of cases) that may calcify 2

Markers

This subtype may increase serum CA-125 levels 2.

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Article Information

rID: 17253
System: Gynaecology
Tags: stub, cases
Synonyms or Alternate Spellings:
  • Papillary serous carcinoma of the uterus
  • Papillary serous carcinoma of uterus
  • Uterine papillary serous carcinoma (UPSC)
  • Uterine papillary serous carcinoma
  • Uterine papillary serous cancer
  • Papillary serous carcinoma of endometrium
  • Papillary serous carcinoma (PSC) of the endometrium

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