Papillary serous carcinoma of the endometrium
Papillary serous carcinoma (PSC) of the endometrium is an uncommon histological subtype of endometrial cancer. It is considered type II endometrial adenocarcinoma and has a clinically aggressive form with early extension of the tumour via Fallopian tubes into the peritoneum and peritoneal seeding which accounts for its poorer prognosis compared to the other adenocarcinomas of the uterus. This is thought to closely resemble ovarian papillary serous carcinoma 1. This subtype only comprises 5-10% of endometrial carcinomas 2.
Like is ovarian counterpart it is characterised by papillary projections and frequently contains psammoma bodies (may be found in ~1/3 of cases) that may calcify 2.
This subtype may increase serum CA-125 levels 2.
- 1. Hendrickson M, Ross J, Eifel P et-al. Uterine papillary serous carcinoma: a highly malignant form of endometrial adenocarcinoma. Am. J. Surg. Pathol. 1982;6 (2): 93-108. - Pubmed citation
- 2. Van mieghem IM, Gryspeerdt S, Baekelandt M et-al. Papillary serous adenocarcinoma of the endometrium: CT-pathologic correlation. AJR Am J Roentgenol. 2004;182 (6): 1534-6. AJR Am J Roentgenol (full text) - Pubmed citation
- 3. Carcangiu ML, Chambers JT. Uterine papillary serous carcinoma: a study on 108 cases with emphasis on the prognostic significance of associated endometrioid carcinoma, absence of invasion, and concomitant ovarian carcinoma. Gynecol. Oncol. 1992;47 (3): 298-305. - Pubmed citation
- 4. FRCPath VKMBBSMD, MBBS AKA, Aster JC. Robbins Basic Pathology. Saunders. (2012) ISBN:1437717810. Read it at Google Books - Find it at Amazon