Paraneoplastic cerebellar degeneration

Paraneoplastic cerebellar degeneration is a type of paraneoplastic syndrome characterised by the progressive onset of cerebellar dysfunction not explained by tumoral invasion, metastasis, or treatment side effects. 

It is an uncommon paraneoplastic syndrome that has been reported in patients with small-cell lung cancer, ovary malignancies, breast carcinoma, and Hodgkin's lymphoma 1

Cerebellar dysfunction may manifest as dizziness, nausea/vomiting, ataxia, diplopia, dysarthria, or dysphagia 1. A rapidly progressing gait unsteadiness is usually the key symptom that prompt for neuroimaging. 

Brain imaging with CT or MRI may show either normal cerebellum, particularly in initial presentation, to eventual diffuse cerebellar atrophy. Cerebellar hemispheric enlargement and cortical-meningeal enhancement have been reported 2

The management is focused on the tumour treatment and supportive therapies. 

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Article Information

rID: 52661
Section: Pathology
Synonyms or Alternate Spellings:
  • Paraneoplastic cerebellar ataxia

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