Paraneoplastic rhombencephalitis corresponds to a perivascular and interstitial inflammatory process affecting the hindbrain (brainstem and cerebellum) associated with a systemic cancer, small cell lung cancer in the majority of cases.
Compared with infectious rhombencephalitis, paraneoplastic syndromes are of slower onset, poorer outcome, and are usually associated with a normal MRI findings. Clinical features and an inflammatory CSF with antineuronal antibodies confirms the diagnosis. It has been associated with anti-Yo, anti-Tr, antiHu, anti-Ri, anti-Ma, and anti-amphiphysin antibodies.
Please refer to the article on rhombencephalitis for a general discussion of that entity.
- 1. Jubelt B, Mihai C, Li TM et-al. Rhombencephalitis / brainstem encephalitis. Curr Neurol Neurosci Rep. 2011;11 (6): 543-52. doi:10.1007/s11910-011-0228-5 - Pubmed citation
- 2. Moragas M, Martínez-Yélamos S, Majós C et-al. Rhombencephalitis: a series of 97 patients. Medicine (Baltimore). 2011;90 (4): 256-61. doi:10.1097/MD.0b013e318224b5af - Pubmed citation