Paraquat included lung disease is a potential consequence of accidental or malintended ingestion of the non selective herbicical agent Paraquat - N,N′-dimethyl-4,4′-bipyridinium dichloride.
Changes tend to progress from air space consolidation to fibrosis.
CT - HRCT Chest
Changes usually being with ground-glass attenuation, which can then to leads to consolidation with bronchiectasis or irregular lines 2.
Some patients may also develop a pneumomediastinum + / - pneumothorax 4.
Focal honeycombing can occur after a few weeks. In patients to tend to survive longer, later imaging (i.e months later) may show aras of localised fibrosis containing small cysts 4.
Once there is lung disease, the condition is thought to carry a very poor prognosis, with most patients progressing to respiratory failure 1-3.
- 1. Hudson M, Patel SB, Ewen SW et-al. Paraquat induced pulmonary fibrosis in three survivors. Thorax. 1991;46 (3): 201-4. Thorax (link) - Free text at pubmed - Pubmed citation
- 2. Lee SH, Lee KS, Ahn JM et-al. Paraquat poisoning of the lung: thin-section CT findings. Radiology. 1995;195 (1): 271-4. Radiology (citation) - Pubmed citation
- 3. Neves FF, Sousa RB, Pazin-filho A et-al. Severe paraquat poisoning: clinical and radiological findings in a survivor. J Bras Pneumol. 36 (4): 513-6. J Bras Pneumol (link) - Pubmed citation
- 4. Im JG, Lee KS, Han MC et-al. Paraquat poisoning: findings on chest radiography and CT in 42 patients. AJR Am J Roentgenol. 1991;157 (4): 697-701. AJR Am J Roentgenol (citation) - Pubmed citation
- 5. Vale JA, Meredith TJ, Buckley BM. Paraquat poisoning: clinical features and immediate general management. Hum Toxicol. 1987;6 (1): 41-7. - Pubmed citation