Parinaud syndrome, also known as the dorsal midbrain syndrome, is a supranuclear vertical gaze disturbance caused by compression of the tectal plate.
It is characterised by a classic triad of findings:
- upward gaze palsy, often manifesting as diplopia
- pupillary light-near dissociation (pupils respond to near stimuli, but not light)
- convergence-retraction nystagmus
It's importance lies in that recognition of Parinaud syndrome localises pathology to impingement of or origin in the tectal plate, most frequently due to a posterior commissure or pineal region mass (typically solid tumours rather than pineal cysts).
History and etymology
Named after Henry Parinaud, a French ophthalmologist (1844-1905).
- 1. Pearce JM. Parinaud's syndrome. J. Neurol. Neurosurg. Psychiatr. 2005;76 (1): 99. doi:10.1136/jnnp.2003.031310 - Free text at pubmed - Pubmed citation
- 2. Jacobs DA, Galetta SL. Neuro-ophthalmology for neuroradiologists. AJNR Am J Neuroradiol. 2007;28 (1): 3-8. AJNR Am J Neuroradiol (full text) - Pubmed citation