Parkinson-plus syndrome

Dr Henry Knipe et al.

Parkinson-plus syndrome refers to a loose group of neurodegenerative disorders that are characterised by features of Parkinson disease but with other neurological symptoms/signs. They have a poor response to levodopa, and mostly have fairly characteristic neuroimaging features. 

Conditions included in Parkinson-plus syndrome include 2,4:

The importance of recognising Parkinson-plus syndrome is that ~25% of patients diagnosed with Parkinson disease end up being diagnosed with a Parkinson-plus syndrome instead 3. Early recognition of features of Parkinson-plus on imaging may help determine an earlier diagnosis and more appropriate treatment. 


Neurodegenerative diseases

Neurodegenerative diseases are legion and their classification just as protean. A useful approach is to divide them according to underlying pathological process, although even using this schema, there is much overlap and thus resulting confusion.

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Article Information

rID: 39698
Sections: Syndromes, Gamuts
Tag: cases
Synonyms or Alternate Spellings:
  • Parkinson-plus disorder

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