Parkinson-plus syndrome

Last revised by Dr Daniel J Bell on 16 Nov 2020

Parkinson-plus syndromes are a loose group of neurodegenerative disorders that are characterized by features of Parkinson disease but with other neurological symptoms/signs. They have a poor response to levodopa, and mostly have fairly characteristic neuroimaging features. 

Conditions included in Parkinson-plus syndrome include 2,4:

The importance of recognizing Parkinson-plus syndromes is that ~25% of patients diagnosed with Parkinson disease end up being diagnosed with a Parkinson-plus syndrome instead 3. Early recognition of features of Parkinson-plus on imaging may help determine an earlier diagnosis and more appropriate treatment. 

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