Citation, DOI, disclosures and article data
At the time the article was created Henry Knipe had no recorded disclosures.View Henry Knipe's current disclosures
At the time the article was last revised Daniel J Bell had no recorded disclosures.View Daniel J Bell's current disclosures
Parkinson-plus syndromes are a loose group of neurodegenerative disorders that are characterized by features of Parkinson disease but with other neurological symptoms/signs. They have a poor response to levodopa, and mostly have fairly characteristic neuroimaging features.
Conditions included in Parkinson-plus syndrome include 2,4:
- progressive supranuclear palsy (PSP)
- multisystem atrophy (MSA)
- dementia with Lewy bodies (DLB)
- cortical-basal ganglionic degeneration (CBGD)
- frontotemporal dementia with chromosome 17 (FTDP-17)
- Pick disease
- Parkinsonism-dementia-amyotrophic lateral sclerosis complex (PDALS)
The importance of recognizing Parkinson-plus syndromes is that ~25% of patients diagnosed with Parkinson disease end up being diagnosed with a Parkinson-plus syndrome instead 3. Early recognition of features of Parkinson-plus on imaging may help determine an earlier diagnosis and more appropriate treatment.