Parotid liposubstitution

Last revised by Dalia Ibrahim on 18 Nov 2023

Parotid liposubstitution is a fatty degeneration of the parotid gland, sometimes increasing in volume.

Parotid liposubstitution is physiological with age but which may be associated with local or systemic conditions that include:

  • hypertriglyceridemia may be associated with fat infiltration without inflammatory activity

  • adnexectomy for decreased ovarian hormones

  • Sjögren's syndrome, for adipose degeneration and lymphocytic infiltration

  • human immunodeficiency virus with fat infiltration, lymphocytic aggregates, lymphoepithelial cysts or lymphadenopathy

  • alcoholics and diabetics

  • aging with an increase in lipids and degeneration of secretory granules

  • lymphoma

  • sarcoidosis

Patients are asymptomatic or present with xerostomia.

MRI the fat deposits on the parotids:

  • T1 and T2: high signal

  • T1 and T2 fat suppression: low signal

  • T1 C+ (Gd): no significant enhancement

Therapy only if associated with systemic pathologies.

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Cases and figures

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