Partial hydatidiform mole

Partial hydatidiform mole (PHD) is a sub type of a hydatidiform mole which in turn falls under the spectrum of gestational trophoblastic disease

Clinical signs and symptoms such as abdominal pain, cramps of the lower abdomen and vaginal bleeding during pregnancy are non specific. The uterus is often large for gestational age, and fetal heart beat is usually absent. 

It is characterised by its focal distribution, slower transformation, the presence of an embryo or fetus, and a triploid karyotype (70% are 69, XXY; 27% are 69, XXX; 3% are 69 XYY). The extra set of chromosomes are often of paternal origin 7.

Antenatal ultrasound

Definitive diagnosis by ultrasound is often difficult. Described sonographic features include 1,3:

  • greatly enlarged placenta relative to the size of the uterine cavity
  • cystic spaces within the placenta ("molar placenta"), which may not always be present
  • an amniotic cavity (gestational sac), either empty or containing amorphous inappropriately small fetal echoes which may be surrounded by a relatively thick rim of placental echoes with intermingling cystic spaces.
  • presence of a well-formed but growth-retarded fetus, either dead or alive with hydropic degeneration of fetal parts being frequently present.
  • some partial moles can have sonographic appearances indistinguishable from those of the common complete moles or missed abortions 3, although an echogenic rim around the sac, as found in missed abortion or blighted ovum, is notably absent

CT and/or MRI evaluation are not usually performed initially but may be used to determine if there is extension of molar tissue outside the uterus. CT may show an enlarged uterus with areas of low attenuation, or hypoattenuating foci surrounded by highly enhanced areas in the myometrium.

Considerations on early ultrasound scans include:

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Article information

rID: 13717
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Partial mole
  • Partial molar pregnancy
  • Partial hydatidiform mole (PHM)

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