Penetrating atherosclerotic ulcer

Penetrating atherosclerotic ulcers (PAU) are a pathology that involves the aortic wall which along with aortic dissection and aortic intramural hematoma form the spectrum known as acute aortic syndrome

Typically, penetrating atherosclerotic ulcers are seen in elderly male patients with a history of hypertension (up to 92%), smoking (up to 77%) and coronary artery disease (up to 46%) as well as chronic obstructive pulmonary disease (24-68%) 1.

Penetrating atherosclerotic ulcers account for ~7.5% (range 2.3-11%) of all cases of acute aortic syndrome 1. In ~50% (range 42-61%) of cases, there are concurrent aortic aneurysms, most often in the abdomen 1.

Typically patients present with symptoms of an acute aortic syndrome, namely acute intense chest pain, often described as tearing, ripping, migrating or pulsating 1,8.

Some of the patients with penetrating atherosclerotic ulcers are asymptomatic and the diagnosis is made incidentally. A Mayo Clinic series showed just 75% of the patients had been symptomatic 2.

The term "penetrating atherosclerotic ulcer" describes an ulcerating atherosclerotic lesion that penetrates the intima and progresses through the internal elastic lamina into the media 17. In the early stages, the lesions just ulcerate the intima and are often asymptomatic. With further progression, they ulcerate into the media and lead to an intramural hematoma of variable size within the media 3.

The penetrating atherosclerotic ulcer can resolve completely or stay stable, but they can also progress to aortic dissection, aortic saccular aneurysms, perforation and spontaneous aortic rupture. There are conflicting reports about the most common course of penetrating atherosclerotic ulcers 1.

Currently, imaging modalities can not reliably determine if an ulcer has penetrated the internal elastic lamina 17. Due to this limitation, it is also difficult to differentiate an ulcerated plaque from a PAU. Some features that may aid this differentiation are:

  • ulcerated plaques have an undulating interface with overlying thrombus whereas a PAU has a smooth interface with the IMH
  • contrast extends beyond intimal calcification in a PAU
  • intimal calcification occurs at the same site as an ulcerated plaque whereas intimal calcification is often remote to a PAU

Patients with PAUs and aortic IMHs have an increased risk of concomitant abdominal aortic aneurysm 17.

There is a greater predilection to involve the aortic arch and mid to distal thoracic aorta 6,22.

PAUs with a depth greater than 10 mm or diameter greater than 20 mm are associated with a higher rate of progression 17.

As with classical aortic dissection, PAUs are classified according to the Stanford scheme.

On CT aortography, the typical finding is a contrast-filled, out-pouching of the wall of the aorta or into the thickened aortic wall in absence of an intimal flap or a false lumen. The protrusion is said to resemble a mushroom 14 and can appear similar to an ulcerated plaque 17. These can progress to an intramural hematoma and often have intramural hematoma adjacent to the ulcer. Often there are signs of extensive atherosclerosis in other sites apart from the ulceration 4

Usually, the ulcer is found in the descending part of the thoracic aorta. Ulcers of the aortic arch are less common, and rare in the ascending aorta 4.

Although associated pleural effusion correlates with clinical instability there are no validated imaging features for the prediction of the course of a PAU 1. It is often difficult to determine if a PAU is the source of a patient's pain or if it is an incidental finding.

In follow-up studies increasing maximum diameter and depth of the ulcer is an obvious sign of progression 1. However, there is currently no consensus for ulcer depth or diameter that warrants treatment 14.

A CTA radiology report of PAUs should include 17:

  • proximal and distal extent of the ulcer
  • presence and thickness of associated intramural hematoma
  • maximal diameter of the affected aortic lumen
  • ulcer saccular depth
  • usually, transesophageal echocardiography demonstrates a localized, crater-like protrusion of the aortic lumen into the thickened aortic wall 9
  • often there are signs of extensive atherosclerosis in other sites apart from the ulceration 9
  • T1-weighted SE sequences show a hyperintense hematoma in acute or subacute disease and can distinguish between hematoma and atherosclerotic plaque 9
  • otherwise similar findings to CTA 9
  • the typical finding is a contrast-filled, pouch-like protrusion of the aortic lumen 9
  • mostly several oblique projections are required 9

No set guidelines on when to treat and practices vary between hospitals, however the general consensus is as follows:

  • ascending aorta
    • although the involvement of the ascending aorta in penetrating atherosclerotic ulcers is rare, the ulcers usually rupture
    • therefore early/urgent or emergent surgical intervention is recommended 4
  • descending aorta
    • asymptomatic:
      • may initially be managed with an aggressive (antihypertensive) medical therapy in combination with close clinical and radiographic follow-up
        • annual CT imaging follow-up has been suggested 10
    • symptomatic or signs of progression:
  • iliac arteries
    • generally asymptomatic/incidental and slow-growing 15
    • mortality is determined by concurrent co-morbidities such as concurrent aortic aneurysm

Recognized complications include:

They were first described as a distinct clinical and pathological entity by Stanson et al. in 1986 3

General imaging differential considerations include:

Article information

rID: 12816
System: Vascular
Synonyms or Alternate Spellings:
  • Penetrating atherosclerotic ulcer (PAU)
  • Penetrating aortic ulcer
  • PAU
  • Penetrating aortic ulcers
  • Penetrating atherosclerotic ulceration
  • Penetrating atherosclerotic ulcers

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Cases and figures

  • Figure 1: diagram of pathogenesis
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  • Figure 2: illustration
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  • Case 1: involving ascending aorta
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  • Penetrating aorti...
    Case 2: involving thoracic aorta : CT
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  • Case 2: involving thoracic aorta : angiography
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  • Case 3
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  • Case 4
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  • Case 5
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  • Case 6: with aortic intramural hematoma
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  • Case 7
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