A periampullary diverticulum is a location-specific type of duodenal diverticulum.
The incidence is reported to increase with age with reported rates as high as 27%.
It is located close to the region of the duodenum often involving the D2 segment.
- can be associated with increased risk of failure for cannulation of the papilla.
- associated with an incompetent sphincter of Oddi and colonization of bile duct with beta-glucuronidase-producing organisms.
- they are implicated in the pathogenesis of pigment common bile duct stones, but there is no conclusive evidence that they are associated with cholecystolithiasis or pancreatitis.
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