Peripheral T cell lymphoma

Last revised by Dr Ali Alsmair on 16 Mar 2022

Peripheral T cell lymphoma is an uncommon, heterogeneous group of lymphoma. It can account for around 5-15% of non-Hodgkin lymphoma (NHL).

The word "peripheral" does not mean involvement in the extremities but refers to tumor cells that arise from lymphoid tissue outside of the bone marrow

This lymphoma type develops from mature-stage T-cells and natural killer (NK) cells.

Peripheral T cell lymphoma can involve various organs including the sinonasal cavity, airway, intestinal tract, skin, lymph nodes, liver, lung, and musculoskeletal system.

Peripheral T cell lymphoma is generally considered to have a poorer outcome 3. Initially, combination therapy regimens are usually offered. Agents such as pralatrexate are used for refractory cases.

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