Perivascular pseudorosettes (ependymoma)
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View Frank Gaillard's current disclosures- Perivascular pseudorosettes
- Perivascular pseudorosette
Perivascular pseudorosettes are a common histologic feature of central nervous system ependymomas. They represent sections through papillary structures composed of tumor cells arranged radially around a central vessel. Between the central vessel and the tumor cells is a relatively microscopically clear region filled with cytoplasmic processes that are strongly positive for GFAP 1,2. In myxopapillary ependymomas, myxoid material will also be present within this clear space, sometimes forming microcysts 1.
Perivascular pseudorosettes should not be confused for features of ependymomas:
- ependymal rosette
- EMA positive perinuclear dot sometimes forming intracytoplasmic microrosettes
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References
- 1. Louis DN, Perry A, Reifenberger G et-al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131 (6): 803-20. doi:10.1007/s00401-016-1545-1 - Pubmed citation
- 2. Frangoise Gray, Charles Duyckaerts, Umberto De Girolami. Escourolle and Poirier's Manual of Basic Neuropathology. 5th EditionISBN: 9780199929054
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