Perivascular pseudorosettes (ependymoma)

Last revised by Frank Gaillard on 3 Feb 2022

Perivascular pseudorosettes are a common histologic feature of central nervous system ependymomas. They represent sections through papillary structures composed of tumor cells arranged radially around a central vessel. Between the central vessel and the tumor cells is a relatively microscopically clear region filled with cytoplasmic processes that are strongly positive for GFAP 1,2. In myxopapillary ependymomas, myxoid material will also be present within this clear space, sometimes forming microcysts 1

Perivascular pseudorosettes should not be confused for features of ependymomas:

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Cases and figures

  • Case 1: ependymoma
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  • Case 2: myxopapillary ependyoma
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  • Case 3: anaplastic ependymoma
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