Perugini grading scale

Last revised by Sally Ayesa ◉ on 3 Jul 2022

Citation, DOI, disclosures and article data

Citation:

Little D, Ayesa S, El-Feky M, et al. Perugini grading scale. Reference article, Radiopaedia.org (Accessed on 28 May 2023) https://doi.org/10.53347/rID-78076

DOI:

https://doi.org/10.53347/rID-78076

Permalink:

https://radiopaedia.org/articles/78076

rID:

78076

Article created:

27 May 2020, David Little ◉

Disclosures:

At the time the article was created David Little had no recorded disclosures.

View David Little's current disclosures

Last revised:

3 Jul 2022, Sally Ayesa ◉

Disclosures:

At the time the article was last revised Sally Ayesa had no financial relationships to ineligible companies to disclose.

View Sally Ayesa's current disclosures

Revisions:

10 times, by 6 contributors - see full revision history and disclosures

Systems:

Cardiac

Sections:

Classifications

Tags:

cardiac amyloidosis, stub, refs, cases

Synonyms:

Perugini score (cardiac amyloidosis)

The Perugini grading scale is a semi-quantitative method of scoring cardiac uptake following injection of 99mTc-DPD, 99mTc-Pyrophosphate or 99mTc-HMDP scintigraphy in the investigation of cardiac amyloidosis (particularly ATTR amyloidosis). The grading scale visually compares tracer uptake in the myocardium and ribs.

Classification

grade 0: no cardiac uptake and normal rib uptake
grade 1: cardiac uptake which is less than rib uptake
grade 2: cardiac uptake with intensity similar rib uptake
grade 3: cardiac uptake greater than rib uptake with mild or absent rib uptake

Visual scores of 2 or greater on planar +/- SPECT/CT imaging are classified as ATTR positive studies. Scores of less than 2 are interpreted as ATTR negative⁴.