Phase-sensitive inversion recovery
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Phase-sensitive inversion recovery (PSIR), also known as phase-corrected inversion recovery (PCIR), refers to an inversion recovery MRI pulse sequence that accounts for the positive and negative polarities and preserves the information of tissue magnetization during the recovery from the initial 180° inversion pulse and factually doubles the dynamic range.
Tissues with more negative longitudinal magnetizations appear darker than those with less negative or more positive magnetizations.
Since the data is reconstructed with the obtained phase information, the images are less dependant on an optimized inversion time. However, the images will be even better if the inversion time is optimized nonetheless.
A drawback compared to other inversion recovery sequences which require selective nulling is its longer acquisition time.
Phase-sensitive inversion recovery sequences have been used for the following 1-7:
cardiac MRI - late gadolinium enhancement 1-4
- contrast-enhanced tissue always displays a higher signal than normal myocardium
- less dependence on the inversion time
brain MRI - detection of lesions in multiple sclerosis 5-7
- good contrast-to-noise ratio efficiency
- can nicely detect cortical and spinal lesions which are of low signal intensity without contrast
- 1. Kellman P, Arai A, McVeigh E, Aletras A. Phase-Sensitive Inversion Recovery for Detecting Myocardial Infarction Using Gadolinium-Delayed Hyperenhancement. Magn Reson Med. 2002;47(2):372-83. doi:10.1002/mrm.10051 - Pubmed
- 2. Huber A, Schoenberg S, Hayes C et al. Phase-Sensitive Inversion-Recovery MR Imaging in the Detection of Myocardial Infarction. Radiology. 2005;237(3):854-60. doi:10.1148/radiol.2373041483 - Pubmed
- 3. Jimenez Juan L, Crean A, Wintersperger B. Late Gadolinium Enhancement Imaging in Assessment of Myocardial Viability. Radiologic Clinics of North America. 2015;53(2):397-411. doi:10.1016/j.rcl.2014.11.004 - Pubmed
- 4. Schultz A, Caspar T, Schaeffer M et al. Late Gadolinium Enhancement Cardiac Imaging on a 3T Scanner with Parallel RF Transmission Technique: Prospective Comparison of 3D-PSIR and 3D-IR. Eur Radiol. 2015;26(6):1547-55. doi:10.1007/s00330-015-4002-y - Pubmed
- 5. Hou P, Hasan K, Sitton C, Wolinsky J, Narayana P. Phase-Sensitive T1 Inversion Recovery Imaging: A Time-Efficient Interleaved Technique for Improved Tissue Contrast in Neuroimaging. AJNR Am J Neuroradiol. 2005;26(6):1432-8. PMC8149049 - Pubmed
- 6. Favaretto A, Poggiali D, Lazzarotto A, Rolma G, Causin F, Gallo P. The Parallel Analysis of Phase Sensitive Inversion Recovery (PSIR) and Double Inversion Recovery (DIR) Images Significantly Improves the Detection of Cortical Lesions in Multiple Sclerosis (MS) Since Clinical Onset. PLoS ONE. 2015;10(5):e0127805. doi:10.1371/journal.pone.0127805 - Pubmed
- 7. Mirafzal S, Goujon A, Deschamps R et al. 3D PSIR MRI at 3 Tesla Improves Detection of Spinal Cord Lesions in Multiple Sclerosis. J Neurol. 2019;267(2):406-14. doi:10.1007/s00415-019-09591-8 - Pubmed