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Pickardt syndrome also known as Pickardt-Fahlbusch syndrome is a rare syndrome characterized by tertiary hypothyroidism, hyperprolactinemia and other pituitary hormone deficiencies resulting from interruption of the portal blood supply of the anterior pituitary via the infundibulum which drains the hypothalamus where numerous controlling hormones are released. Such interruption can be congenital (pituitary stalk interruption syndrome) or acquired due to surgery or trauma 1.
Hypothyroidism is associated with low thyroid-stimulating hormone (TSH) which relies upon the secretion of thyroid releasing hormone (TRH) from the hypothalamus.
In contrast, elevated prolactin results from lack of tonic inhibition of secretion of prolactin by prolactin inhibitory hormone (PIH) better known as dopamine 2.