There is a marked male predominance with a M:F of ~13:1. Most patients are 20 years or younger at the time of diagnosis.
See main article: intracranial germ cell tumours.
Treatment and prognosis
Leptomeningeal or intraventricular spread is not uncommon (occurring in 13% 2) at the time of diagnosis. Germinomas are receptive to radiation therapy and survival rates of ~85% are reported 3.
See pineal region mass article.
- 1. Villano JL, Propp JM, Porter KR et-al. Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries. Neuro-oncology. 2008;10 (2): 121-30. Neuro-oncology (full text) - doi:10.1215/15228517-2007-054 - Free text at pubmed - Pubmed citation
- 2. Fang AS, Meyers SP. Magnetic resonance imaging of pineal region tumours. Insights Imaging. 2013;4 (3): 369-82. doi:10.1007/s13244-013-0248-6 - Free text at pubmed - Pubmed citation
- 3. Reddy MP, Saad AF, Doughty KE et-al. Intracranial germinoma. Proc (Bayl Univ Med Cent). 2015;28 (1): 43-5. Free text at pubmed - Pubmed citation
- 4. Al-Hussaini M, Sultan I, Abuirmileh N et-al. Pineal gland tumors: experience from the SEER database. J. Neurooncol. 2009;94 (3): 351-8. doi:10.1007/s11060-009-9881-9 - Free text at pubmed - Pubmed citation
Pineal region masses
The pineal region is anatomically complex and plays host to a number of unique masses and tumours as well as potentially affected by many entities seen more frequently elsewhere in the brain.
- cystic non-neoplastic lesions
- pineal parenchymal tumours
- germ cell tumours
- tumours also encountered in the pineal region
- pineal gland metastases
- vascular lesions