Pineal gland metastases

Pineal gland metastases are rare and mostly related to primary carcinomas of the lungs, breast, gastrointestinal tract, and kidneys. They usually occur concomitantly with leptomeningeal metastases.  

This article will discuss metastatic lesions affecting only the pineal gland. For other intracranial metastatic locations, please refer to the main article on intracranial metastases

It is not clear the real incidence of pineal metastasis, studies have reported a prevalence of 0.4 to 3.8% in patients with metastatic solid tumours 1

Pineal metastases are usually asymptomatic unless a certain volume is reached, then causing a local mass effect that may manifest as a Parinaud syndrome or increased intracranial pressure symptoms related to obstructive hydrocephalus 1,3

All the masses that may affect the pineal region are considered among the differential diagnosis. There are no specific imaging features for a metastasis to the pineal gland itself, with the clinical history and the concomitant leptomeningeal carcinomatosis playing a more important role in this scenario. 

Pineal region masses

The pineal region is anatomically complex and plays host to a number of unique masses and tumours as well as potentially affected by many entities seen more frequently elsewhere in the brain. 

General reading

Pathology 

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Article information

rID: 42020
Section: Pathology
Synonyms or Alternate Spellings:
  • Pineal metastasis
  • Pineal gland metastasis
  • Pineal metastases

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Cases and figures

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    Case 1: renal cell carcinoma
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    Case 2: lung cancer
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