Pituitary choristomas, also known as granular cell tumours of the pituitary, is a somewhat controversial term which in the past was thought to be equivalent to a pituicytoma, but in fact represent a histologically separate entity.
Granular cell tumours of the pituitary are composed of sheets of large polyhedral cells, with abundant eosinophilic cytoplasm filled with periodic acid-Schiff–positive granules 1-2. They have only focal spindled areas (in contrast to pituicytomas). They are usually negative for GFAP 2.
Pituitary region masses
- pituitary adenoma (commonest in the adult population)
- hypothalamic astrocytoma/glioma
- chiasmatic astrocytoma
- optic nerve glioma
- dermoid (CNS) / epidermoid / intracranial teratoma
- pituitary metastases
- granular cell tumour of the pituitary (pituitary choristoma)
- pilocytic astrocytoma of the neurohypophysis (infundibuloma)
- cellular infiltrates
- other lesions
- 1. Brat DJ, Scheithauer BW, Staugaitis SM et-al. Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am. J. Surg. Pathol. 2000;24 (3): 362-8. Am. J. Surg. Pathol. (link) - Pubmed citation
- 2. 1. Gibbs WN, Monuki ES, Linskey ME et-al. Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol. 2006;27 (8): 1639-42. AJNR Am J Neuroradiol (full text) - Pubmed citation