Pituitary hyperplasia

Pituitary hyperplasia refers to the diffuse pituitary enlargement that can be physiological in young menstruating females or pregnant/lactating women or, less commonly, secondary to end-organ failure.

The upper limit of normal pituitary height varies with age and gender 1:

  • infants, children: 6 mm
  • males and postmenopausal women: 8 mm
  • young menstruating females: 10 mm
  • pregnant/lactating women: 12 mm

Non-physiologic pituitary hyperplasia is commonly caused by an end-organ failure such as hypothyroidism 3Addison disease 4 and neuroendocrine tumors 5. Medications such as estrogen, GnRH analogs and antipsychotics can cause or exacerbate pituitary hyperplasia 5.

The pituitary gland can be assessed both by CT and MRI dedicated protocols, which can show the following: 1

  • enlarged homogeneously enhancing pituitary gland with a convex superior margin
  • size : >10 mm up to 15 mm
  • maybe globular/nodular, mimicking pituitary adenoma

Only surveillance is suggested until reversal of the underlying pathological condition as pituitary hyperplasia rarely progresses 5.

Article information

rID: 42023
Synonyms or Alternate Spellings:
  • Pituitary hypertrophy
  • Bulky pituitary gland
  • Globular pituitary gland

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Cases and figures

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  • Case 2
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